DZ2002 is a potent, reversible type III inhibitor of SAHH (S-adenosyl-L-homocysteine hydrolase) with Ki of 17.9 nM.
DZ2002 is more effectively than type I inhibitor DHCaA with greatly reduced cytotoxicity.
DZ2002 significantly reduces both a mixed lymphocyte reaction and IL-12 production from in vitro-stimulated splenocytes.
DZ2002 suppresses a delayed-type hypersensitivity reaction and antibody secretion in vivo.
