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Chemical Structure : Dafadine-A
CAS No.: 1065506-69-5
Catalog No.: PC-38446Not For Human Use, Lab Use Only.
Dafadine-A is a small molecule inhibitor of DAF-9 cytochrome P450, binds DAF-9 and specifically inhibits its enzymatic activity, promotes dauer formation and longevity of Caenorhabditis elegans.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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Dafadine-A is a small molecule inhibitor of DAF-9 cytochrome P450, binds DAF-9 and specifically inhibits its enzymatic activity, promotes dauer formation and longevity of Caenorhabditis elegans.
Dafadine-A robustly induces dauer formation in typical culture conditions, also inhibits the mammalian ortholog of DAF-9(CYP27A1).
Specific chemical inhibition of DAF-9 (cytochrome P450) via Dafadine-A was shown to significantly reduce the amount of endogenous dafachronic acid (DA) in H. contortus.
The DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematode Caenorhabditis elegans.
| M.Wt | 391.471 | |
| Formula | C23H25N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[1-({5-[(2,6-dimethylphenoxy)methyl]-3-isoxazolyl}carbonyl)-4-piperidinyl]-pyridine |
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1. Genna M Luciani, et al. Nat Chem Biol. 2011 Nov 6;7(12):891-3.
2. Guangxu Ma, et al. PLoS Pathog . 2019 Jul 23;15(7):e1007960.
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