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Chemical Structure : Dantrolene
CAS No.: 7261-97-4
Catalog No.: PC-20389Not For Human Use, Lab Use Only.
Dantrolene (F368) is a muscle relaxant, non-competitively inhibitor of human erythrocyte glutathione reductase with Ki and IC50 values are 111.6 μM and 52.3 μM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $98 | In stock | |
| 100 mg | $188 | In stock | |
| 250 mg | $298 | In stock | |
| 1 g | Get quote |
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Dantrolene (F368) is a muscle relaxant, non-competitively inhibitor of human erythrocyte glutathione reductase with Ki and IC50 values are 111.6 μM and 52.3 μM, respectively.
Dantrolene is a ryanodine receptor (RyR) antagonist and Ca2+ signaling stabilizer.
Dantrolene interferes with calcium release from the sarcoplasmic reticulum and thus to inhibit excitation-contraction coupling.
Dantrolene depresses excitation-contraction coupling in muscle fibers by inhibiting calcium release from the sarcoplasmic reticulum.
Dantrolene affects the membrane calcium channel of smooth muscle cells and inhibits calcium influx.
Dantrolene binds to domain 601-620 of RyR2 and corrects defective inter-domain interaction within RyR2 in failing hearts.
| M.Wt | 314.26 | |
| Formula | C14H10N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,4-Imidazolidinedione, 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]- |
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1. W J Meyler, et al. Eur J Pharmacol. 1979 Feb 1;53(4):335-42.
2. F Zhao, et al. J Biol Chem. 2001 Apr 27;276(17):13810-6.
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