Debecarasib

Chemical Structure : Debecarasib

Catalog No.: PC-27417Not For Human Use, Lab Use Only.

Debecarasib is a potent and orally bioavailable inhibitor of GDP-bound KRAS G12D, shows highly selectivity for KRAS G12D against wild-type KRAS and other RAS mutations or amplifications.

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Biological Activity

Debecarasib is a potent and orally bioavailable inhibitor of GDP-bound KRAS G12D, shows highly selectivity for KRAS G12D against wild-type KRAS and other RAS mutations or amplifications.

Physicochemical Properties

M.Wt	706.79
Formula	C35H37F3N8O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Thieno[3,2-c]pyridine-3-carbonitrile, 2-amino-7-fluoro-4-[5-fluoro-3-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]-7,9-dihydro-1-[3-[(2R)-2-hydroxypropyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]furo[3,4-f]quinazolin-6-yl]-

References

1. Patent WO2023183585 A1 2023-09-28.

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Debecarasib

Biological Activity

Physicochemical Properties

References

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