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Chemical Structure : Debromohymenialdisine
Catalog No.: PC-60291Not For Human Use, Lab Use Only.
Debromohymenialdisine (SKF108753) is a marine sponge alkaloid that inhibits Chk1 and Chk2 with IC50 of 3 and 3.5 uM, respectively.
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Debromohymenialdisine (SKF108753) is a marine sponge alkaloid that inhibits Chk1 and Chk2 with IC50 of 3 and 3.5 uM, respectively.
Debromohymenialdisine also inhibits MAP kinase kinase 1 (IC50=881 nM), GSK3β (IC50=1.39 uM), and CDK5/p25 (IC50=9.12 uM), does not significantly affect ATM and ATR.
Debromohymenialdisine blocks G2 arrest in cancer cells.
| M.Wt | 245.2 | |
| Formula | C11H11N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Curman D, et al. J Biol Chem. 2001 May 25;276(21):17914-9.
2. Saleem RS, et al. Bioorg Med Chem. 2012 Feb 15;20(4):1475-81.
3. Jobson AG, et al. Mol Pharmacol. 2007 Oct;72(4):876-84.
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