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Decitabine

Chemical Structure : Decitabine

CAS No.: 2353-33-5

Decitabine (5-Aza-2'-deoxycytidine, 5-AZA-CdR)

Catalog No.: PC-27598Not For Human Use, Lab Use Only.

Decitabine (5-Aza-2'-deoxycytidine, 5-AZA-CdR) is an orally active deoxycytidine analogue antimetabolite and DNA methyltransferase (DNMT) inhibitor, incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme, induces cell G2/M arrest and cell apoptosis.

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Biological Activity

Decitabine (5-Aza-2'-deoxycytidine, 5-AZA-CdR) is an orally active deoxycytidine analogue antimetabolite and DNA methyltransferase (DNMT) inhibitor, incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme, induces cell G2/M arrest and cell apoptosis.

Physicochemical Properties

M.Wt 228.21
Formula C8H12N4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one

References

1. Hagemann S, et al. PLoS One. 2011 Mar 7;6(3):e17388.

2. Yu J, et al. J Clin Invest. 2018 Jun 1;128(6):2376-2388.

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