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Chemical Structure : Dersimelagon
CAS No.: 1835256-48-8
Catalog No.: PC-35446Not For Human Use, Lab Use Only.
Dersimelagon (MT-7117) is an orally bioavailable selective, non-peptide melanocortin-1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14 and 0.251 nM for human, cynomolgus monkey, mouse and rat MC1R, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Dersimelagon (MT-7117) is an orally bioavailable selective, non-peptide melanocortin-1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14 and 0.251 nM for human, cynomolgus monkey, mouse and rat MC1R, respectively.
Dersimelagon (MT-7117) shows good affinity for hMC1R and hMC4R with Ki values of 2.26, 32.9 nM, respectively.
Dersimelagon (MT-7117) increases eumelanin production in a concentration-dependent manner, with EC50 of 13 pM in B16F1 cells.
| M.Wt | 675.766 | |
| Formula | C36H45F4N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-{2-[(3S,4R)-1-[(3R,4R)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl)pyrrolidine-3-carbonyl]-4-(methoxymethyl)pyrrolidin-3-yl]-5-(trifluoromethyl)phenyl}piperidine-4-carboxylic acid |
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1. Angelika L Erwin, et al. Diagnostics (Basel). 2021 Sep 29;11(10):1795.
2. T. Suzuki, et al. Skin Health Dis. 2022; 2(1):e78.
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