BMS-986165 (Deucravacitinib, BMS986165) is potent, high selective allosteric inhibitor of TYK2 with Ki of 0.02 nM, IC50 of 0.2 nM.
BMS-986165 binds to the TYK2 pseudokinase (JH2) domain, displays unprecedented JAK isoform and kinome selectivity.
BMS-986165 shows excellent pharmacokinetic properties with minimal profiling liabilities and is efficacious in several murine models of autoimmune disease.
