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Deutivacaftor

Chemical Structure : Deutivacaftor

CAS No.: 1413431-07-8

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Deutivacaftor (VX-561, CTP-656, Ivacaftor-d9, VX-770-d9)

Catalog No.: PC-23052Not For Human Use, Lab Use Only.

Deutivacaftor (VX-561, CTP-656, Ivacaftor-d9) is a potent, orally active CFTR potentiator/modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Deutivacaftor (VX-561, CTP-656, Ivacaftor-d9) is a potent, orally active CFTR potentiator/modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE.

Physicochemical Properties

M.Wt 401.55
Formula C24H19D9N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-(tert-butyl)-5-hydroxy-4-(2-(methyl-d3)propan-2-yl-1,1,1,3,3,3-d6)phenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

References

1. Uluer AZ, et al. Lancet Respir Med. 2023 Jun;11(6):550-562.

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