Chemical Structure : Dexfadrostat
CAS No.:
102676-87-9
Dexfadrostat
((R)-Fadrozole, (R)-CGS 16949A, FAD286)
Catalog No. : PC-73413Not For Human Use, Lab Use Only.
Dexfadrostat ((R)-Fadrozole, CGS 16949A, FAD286) is a potent nonsteroidal inhibitor of aldosterone synthase (CYP 11B2, steroid 18-hydroxylase), also inhibits human placental aromatase (pIC50=6.17).
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-7341301
Biological Activity
Dexfadrostat ((R)-Fadrozole, CGS 16949A, FAD286) is a potent nonsteroidal inhibitor of aldosterone synthase (CYP 11B2 , steroid 18-hydroxylase), also inhibits human placental aromatase (pIC50=6.17).
Physicochemical Properties
M.Wt
223.279
Formula
C14H13N3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Benzonitrile, 4-[(5R)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]-
References
1. Furet P, et al. J Med Chem.
2. Minnaard-Huiban M, et al. Endocrinology.
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