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Dexpramipexole dihydrochloride

Chemical Structure : Dexpramipexole dihydrochloride

CAS No.: 104632-27-1

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Dexpramipexole dihydrochloride ((R)-Pramipexole;KNS-760704)

Catalog No.: PC-45174Not For Human Use, Lab Use Only.

A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively; also possesses low/insignificant affinity (500–10,000 nM) for the 5-HT1A, 5-HT1B, 5-HT1D, and α2-adrenergic receptors; used for treating Parkinson's disease (PD) and restless legs syndrome (RLS).

Alzheimer's Disease

Phase 2 Clinical

Physicochemical Properties

M.Wt 284.249
Formula C10H19Cl2N3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 28 mg/mL
Chemical Name/SMILES

2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, hydrochloride (1:2), (6R)-

References

1. Alavian KN, et al. Brain Res. 2012 Mar 29;1446:1-11.

2. Cudkowicz M, et al. Nat Med. 2011 Nov 20;17(12):1652-6.

3. Bozik ME, et al. J Clin Pharmacol. 2011 Aug;51(8):1177-85.

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