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Dexrazoxane

Chemical Structure : Dexrazoxane

CAS No.: 24584-09-6

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Dexrazoxane (ICRF-187;NSC-169780)

Catalog No.: PC-46752Not For Human Use, Lab Use Only.

A derivative of EDTA that chelates iron and reduces the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals.

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100 mg $104 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A derivative of EDTA that chelates iron and reduces the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals; protects the heart against the cardiotoxic side effects of chemotherapeutic drugs.

Chemotherapeutic Agents

Approved

Physicochemical Properties

M.Wt 268.2691
Formula C11H16N4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,6-Piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-

References

1. Lipshultz SE, et al. N Engl J Med. 2004 Jul 8;351(2):145-53.

2. Bjelogrlic SK, et al. Exp Biol Med (Maywood). 2007 Dec;232(11):1414-24.

3. Jones RL, et al. Expert Rev Cardiovasc Ther. 2008 Nov;6(10):1311-7.

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