Chemical Structure : Dichloro-all-trans-retinone
CAS No.:
2089135-65-7
Dichloro-all-trans-retinone
(DAR)
Catalog No.: PC-72688Not For Human Use, Lab Use Only.
Dichloro-all-trans-retinone (DAR) is an irreversible inhibitor of retinaldehyde dehydrogenase (RALDH/ALDH1A) with IC50 of 434/55/161 nM for RALDH1/RALDH2/RALDH3.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Dichloro-all-trans-retinone (DAR) is an irreversible inhibitor of retinaldehyde dehydrogenase (RALDH/ALDH1A) with IC50 of 434/55/161 nM for RALDH1/RALDH2/RALDH3.
Dichloro-all-trans-retinone has no activity on human mitochondrial ALDH2.
Dichloro-all-trans-retinone inhibits ATRA synthesis in a RALDH2 expressing cell line with IC50 of 3 uM.
The retinaldehyde dehydrogenase (RALDH, also ALDH1A) subfamily consists of three members, RALDH1 (ALDH1A1), RALDH2 (ALDH1A2), and RALDH3 (ALDH1A3), which synthesize all-trans-retinoic acid (ATRA) from retinaldehyde.
Physicochemical Properties
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M.Wt
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367.354
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Formula
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C21H28Cl2O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3E,5E,7E,9E)-1,1-dichloro-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,5,7,9-tetraen-2-one
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References
1. Angelica R Harper, et al. Bioorg Med Chem. 2018 Dec 1;26(22):5766-5779.
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