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Dihydromunduletone

Chemical Structure : Dihydromunduletone

CAS No.: 674786-20-0

Dihydromunduletone

Catalog No.: PC-60594Not For Human Use, Lab Use Only.

Dihydromunduletone is a rotenoid derivative that selectively inhibits GPR56 (IC50=21 uM) and GPR114/ADGRG5, but not GPR110 or Class A GPCRs.

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Biological Activity

Dihydromunduletone is a rotenoid derivative that selectively inhibits GPR56 (IC50=21 uM) and GPR114/ADGRG5, but not GPR110 or Class A GPCRs.
Dihydromunduletone maximally inhibits GPR56 at 50 uM, also dramatically inhibits GPR114 7TM–stimulated Gs activity.
Dihydromunduletone also inhibit the growth of the zebrafish intersegmental vessels.

Physicochemical Properties

M.Wt 424.493
Formula C25H28O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(3,4-Dihydro-3,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2-(5-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)ethanone

References

1. Stoveken HM, et al. Mol Pharmacol. 2016 Sep;90(3):214-24.

2. Wang C, et al. Eur Urol. 2010 Sep;58(3):418-26.

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