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Dimethylenastron

Chemical Structure : Dimethylenastron

CAS No.: 863774-58-7

Dimethylenastron (Kinesin Eg5 inhibitor)

Catalog No.: PC-45755Not For Human Use, Lab Use Only.

Dimethylenastron is a small molecule inhibitor of the mitotic kinesin Eg5.

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Biological Activity

Dimethylenastron is a small molecule inhibitor of the mitotic kinesin Eg5.
Dimethylenastron inhibits endothelial cell proliferation and migration in vitro.
Dimethylenastron exhibits a shorter mitotic arrest, bipolar or multipolar karyokinesis, followed by apoptosis of the daughter cells in dimethylenastron-treated tetraploid cells.

Physicochemical Properties

M.Wt 302.3913
Formula C16H18N2O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 31 mg/mL

Chemical Name/SMILES

5(1H)-Quinazolinone, 2,3,4,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-

References

1. Rello-Varona S, et al. Cell Cycle. 2009 Apr 1;8(7):1030-5.

2. Exertier P, et al. Oncotarget. 2013 Dec;4(12):2302-16.

3. Kaan HY, et al. J Med Chem. 2010 Aug 12;53(15):5676-83.

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