Dimethyl fumarate (DMF, BG-12) exerts anti-inflammatory and pro-metabolic effects in a variety of cell types, activates the Nrf2 pathway.
Dimethyl fumarate has an effective novel treatment for multiple sclerosis.
Dimethyl fumarate activates the Nrf2 pathway and has been identified as a nicotinic acid receptor agonist in vitro.
Physicochemical Properties
M.Wt
144.1253
Formula
C6H8O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: 9.6 mg/mL
Chemical Name/SMILES
2-Butenedioic acid (2E)-, 1,4-dimethyl ester
References
1. Peng H, et al. J Biol Chem. 2012 Aug 10;287(33):28017-26.
2. Ashrafian H, et al. Cell Metab. 2012 Mar 7;15(3):361-71.
