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Dioctatin A

Chemical Structure : Dioctatin A

CAS No.: 138146-67-5

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Dioctatin A

Catalog No.: PC-25331Not For Human Use, Lab Use Only.

Dioctatin A is a metabolite of Streptomyces and an inhibitor of human dipeptidyl aminopeptidase II (DPP-II), inhibits aflatoxin production by Aspergillus parasiticus with IC50 of 0.4 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Dioctatin A is a metabolite of Streptomyces and an inhibitor of human dipeptidyl aminopeptidase II (DPP-II), inhibits aflatoxin production by Aspergillus parasiticus with IC50 of 0.4 uM.
Dioctatin A reduces the mRNA levels of aflatoxin biosynthetic genes and the regulatory gene aflR, inhibit conidiation and decrease the mRNA level of the brlA gene, and also promote kojic acid production.
Dioctatin A inhibits sterigmatocystin production.

Physicochemical Properties

M.Wt 397.56
Formula C21H39N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((S)-3-((2S,3S)-3-amino-2-methyloctanamido)octanamido)but-2-enoic acid

References

1. Yoshinari T, et al. Microbiology (Reading). 2007 Aug;153(Pt 8):2774-2780.

2. Furukawa T, et al. Cell Chem Biol. 2020 Nov 19;27(11):1396-1409.e10.

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