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Chemical Structure : Diprovocim
CAS No.: 2170867-89-5
Catalog No.: PC-35621Not For Human Use, Lab Use Only.
Diprovocim is a potent Toll-like receptor TLR1/TLR2 agonist that induces dose-dependent TNF production with EC50 of 110 pM in human THP-1 cells and 1.3 nM in primary mouse peritoneal macrophages.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Diprovocim is a potent Toll-like receptor TLR1/TLR2 agonist that induces dose-dependent TNF production with EC50 of 110 pM in human THP-1 cells and 1.3 nM in primary mouse peritoneal macrophages.
Diprovocim induces TNF production in bone marrow-derived dendritic cells (BMDC) with EC50 of 6.7 nM, also induces IL-6 production by mouse BMDC.
Diprovocim induces phosphorylation of IKKα, IKKβ, p38, JNK, and ERK, as well as degradation of IκBα in THP-1 cells and mouse peritoneal macrophages, activates conventional TLR1/TLR2 signaling, including MAPK and canonical NF-κB signaling.
Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice.
| M.Wt | 909.1 | |
| Formula | C56H56N6O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3S,3'S,4S,4'S)-1,1'-terephthaloylbis(N3,N4-bis((1S,2R)-2-phenylcyclopropyl)pyrrolidine-3,4-dicarboxamide) |
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1. Wang Y, et al. Proc Natl Acad Sci U S A. 2018 Aug 27. pii: 201809232.
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