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Diptoindonesin G

Chemical Structure : Diptoindonesin G

CAS No.: 1190948-58-3

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Diptoindonesin G (Dip G)

Catalog No.: PC-60204Not For Human Use, Lab Use Only.

A natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells; targets CHIP ubiquitin E3 ligase to modulate ER protein stability, enhances the transcription and anti-proliferative activities of ERβ, while attenuating the transcription and proliferative effects of ERα; the first small molecule that can restore the balance of ERα and ERβ.

Physicochemical Properties

M.Wt 360.321
Formula C21H12O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4,7,9-trihydroxy-1-(4-hydroxyphenyl)-6H-anthra[1,9-bc]furan-6-one

References

1. Zhao Z, et al. Chem Biol. 2015 Dec 17;22(12):1608-21.

2. Juliawaty LD, et al. Nat Prod Commun. 2009 Jul; 4(7):947-50.

3. Gao J, et al. Cell Death Dis. 2017 May 4;8(5):e2765.

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