Catalog No.: PC-22705Not For Human Use, Lab Use Only.
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1) with IC50 of 0.13 uM for ALDH1A1 and 3.4 uM for ALDH2, also inhibits USP2 and USP21 with IC50 of 25.0 and 3.7 uM respectively.
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1) with IC50 of 0.13 uM for ALDH1A1 and 3.4 uM for ALDH2, also inhibits USP2 and USP21 with IC50 of 25.0 and 3.7 uM respectively.
Disulfiram also inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells.
Physicochemical Properties
M.Wt
296.52
Formula
C10H20N2S4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Bis(diethylthiocarbamoyl) disulfide
References
1. Lipsky J.J., et al. Chem. Biol. Interact. 2001;130–132:93–102.
2. Lin HC, et al. Int J Biol Macromol. 2021 Apr 15;176:490-497.
