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Divin

Chemical Structure : Divin

CAS No.: 1443321-11-6

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Divin (Iron chelator)

Catalog No.: PC-60169Not For Human Use, Lab Use Only.

Divin is a potent chelator of iron that arrests late stages of cytokinesis by blocking the physical process of constriction in dividing cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Divin is a potent chelator of iron that arrests late stages of cytokinesis by blocking the physical process of constriction in dividing cells.
    Divin also is a small molecule inhibitor of bacterial divisome assembly.
    Divin downregulates the transcription of genes encoding proteins involved in cell division, reduce protein biosynthesis, and affects the spatiotemporal localization of the division machinery.

    Physicochemical Properties

    M.Wt 372.428
    Formula C22H20N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-N'-((2-hydroxynaphthalen-1-yl)methylene)-3-(2-methyl-1H-benzo[d]imidazol-1-yl)propanehydrazide

    References

    1. Santos TMA, et al. ACS Chem Biol. 2017 Dec 11. doi: 10.1021/acschembio.7b00560.

    2. Eun YJ, et al. J Am Chem Soc. 2013 Jul 3;135(26):9768-76.

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