Catalog No.: PC-21429Not For Human Use, Lab Use Only.
Dp44mT is an iron chelator with selective anticancer activity, exhibits wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics.
Dp44mT is an iron chelator with selective anticancer activity, exhibits wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics. Dp44mT induces DNA double-strand breaks quantified as S139 phosphorylated histone foci (gamma-H2AX) and Comet tails induced in MDA-MB-231 cells. Dp44mT causes up-regulation of the Fe-responsive tumor growth and metastasis suppressor Ndrg1 in the tumor but not in the liver, indicating a potential mechanism of selective anticancer activity. Dp44mT is cytotoxic to breast cancer cells, at least in part, due to selective inhibition of top2alpha.
