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Chemical Structure : Dp44mT
CAS No.: 152095-12-0
Catalog No.: PC-21429Not For Human Use, Lab Use Only.
Dp44mT is an iron chelator with selective anticancer activity, exhibits wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $118 | In stock | |
| 50 mg | $188 | In stock | |
| 100 mg | $288 | In stock | |
| 1 g | Get quote |
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Dp44mT is an iron chelator with selective anticancer activity, exhibits wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics.
Dp44mT induces DNA double-strand breaks quantified as S139 phosphorylated histone foci (gamma-H2AX) and Comet tails induced in MDA-MB-231 cells.
Dp44mT causes up-regulation of the Fe-responsive tumor growth and metastasis suppressor Ndrg1 in the tumor but not in the liver, indicating a potential mechanism of selective anticancer activity.
Dp44mT is cytotoxic to breast cancer cells, at least in part, due to selective inhibition of top2alpha.
| M.Wt | 285.37 | |
| Formula | C14H15N5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone |
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1. Yu Y, et al. Mol Pharmacol. 2011 Jun;79(6):921-31.
2. Debebe Z, et al. Mol Pharmacol. 2011 Jan;79(1):185-96.
3. Rao VA, et al. Cancer Res. 2009 Feb 1;69(3):948-57.
4. Whitnall M, et al. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14901-6.
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