Chemical Structure : Dual CYP19A1/CYP11B2 inhibitor X21
CAS No.:
183500-36-9
Dual CYP19A1/CYP11B2 inhibitor X21
(X21)
Catalog No.: PC-21449Not For Human Use, Lab Use Only.
Dual CYP19A1/CYP11B2 inhibitor X21 is a potent and selective dual inhibitor of aromatase (CYP19A1) and aldosterone synthase (CYP11B2) with IC50 of 2.3 nM and 29 nM, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Dual CYP19A1/CYP11B2 inhibitor X21 is a potent and selective dual inhibitor of aromatase (CYP19A1) and aldosterone synthase (CYP11B2) with IC50 of 2.3 nM and 29 nM, respectively.
X21 shows high selectivity with respect to 11β-hydroxylase (CYP11B1), as well as CYP3A4 and CYP1A2.
X21 shows potent antiproliferative activity against BC cell lines, particularly against the ER+ MCF-7 cells (IC50 of 0.26 μM at 72 h), and a remarkable pro-apoptotic effect.
X21 significantly inhibits mTOR phosphorylation, thereby negatively modulating the PI3K/Akt/mTOR axis.
Physicochemical Properties
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M.Wt
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213.24
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Formula
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C12H11N3O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-((5-(Hydroxymethyl)-1H-imidazol-1-yl)methyl)benzonitrile
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References
1. Annachiara Tinivella, et al. ACS Pharmacology & Translational Science. 2023.
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