Chemical Structure : Dual GO/LDHA inhibitor 2
CAS No.:
Dual GO/LDHA inhibitor 2
(OPPFSA 2)
Catalog No.: PC-25944Not For Human Use, Lab Use Only.
Dual GO/LDHA inhibitor 2 is a first-in-class, orally bioavailable dual inhibitor of glycolate oxidase (GO) and lactate dehydrogenase A (LDHA) with Ki of 390 nM and 40 nM, also promotes hydrophobic tag-mediated autophagic degradation of LDHA.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Dual GO/LDHA inhibitor 2 is a first-in-class, orally bioavailable dual inhibitor of glycolate oxidase (GO) and lactate dehydrogenase A (LDHA) with Ki of 390 nM and 40 nM, also promotes hydrophobic tag-mediated autophagic degradation of LDHA.
Dual GO/LDHA inhibitor 2 (20 mg/kg/day) degrades hepatic LDHA, decreases urinary oxalate, and diminishes renal deposition of calcium-oxalate crystals in the liver of PH1 mice.
Dual GO/LDHA inhibitor 2 (20 mg/kg body weight) exhibits a significant reduction in urinary oxalate levels and urinary glycolate levels at the renal level of PH1 mice.
Physicochemical Properties
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M.Wt
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577.72
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Formula
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C37H39NO5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-{5-{(E)-3-{4-[6-(Adamantan-1-ylmethylamino)hex-1-ynyl]phenyl}-3-oxoprop-1-enyl}furan-2-yl}-2-hydroxybenzoic Acid
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References
1. Arias F, et al. J Med Chem. 2026 Jan 2. doi: 10.1021/acs.jmedchem.5c02055.
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