Dual PI3K/BET 18DS

Chemical Structure : Dual PI3K/BET 18DS

Catalog No.: PC-21267Not For Human Use, Lab Use Only.

Dual PI3K/BET 18DS is a potent, chimeric dual PI3K/BET bromodomain inhibitor, demonstrates high selectivity, nanomolar range cellular potency, and compelling in vivo efficacy.

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Biological Activity

Dual PI3K/BET 18DS is a potent, chimeric dual PI3K/BET bromodomain inhibitor, demonstrates high selectivity, nanomolar range cellular potency, and compelling in vivo efficacy.

Physicochemical Properties

M.Wt	617.71
Formula	C34H35N9O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(4-(1-acetyl-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzyl)-6-(2-aminopyrimidin-5-yl)-8-morpholinoimidazo[1,2-a]pyrazine-2-carboxamide

References

1. Danielle H Oh, et al. Proc Natl Acad Sci U S A. 2023 Sep 5;120(36):e2306414120.

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