Chemical Structure : E09241
CAS No.:
1043110-13-9
E09241
(E 09241, E-09241)
Catalog No.: PC-22207Not For Human Use, Lab Use Only.
E09241 is a small molecule osteoprotegerin (OPG) upregulator with EC50 of 1.23 uM, effectively promotes osteogenesis and inhibits osteoclastogenesis through activating the PPARδ signaling pathway.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
E09241 is a small molecule osteoprotegerin (OPG) upregulator with EC50 of 1.23 uM, effectively promotes osteogenesis and inhibits osteoclastogenesis through activating the PPARδ signaling pathway.
E09241 increased the alkaline phosphatase (ALP) activity of mouse osteoblasts, promoted mineralization, and increased the expression of osteogenic differentiation-related genes.
E09241 inhibited RANKL-induced osteoclast differentiation and reduced the expression of osteoclast differentiation-related proteins nuclear factor of activated T cells c1 (NFATc1) and matrix metalloproteinase 9 (MMP-9).
E09241 exerted therapeutic protection against bone loss in ovariectomized rats in vivo.
Physicochemical Properties
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M.Wt
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236.66
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Formula
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C11H9ClN2O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-chloro-N-(4-methylpyridin-2-yl)furan-2-carboxamide
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References
1. Han X, et al. Front Pharmacol. 2019 Mar 11;10:103.
2. Yining Li, et al. Bioorg Chem. 2024 Apr 11:147:107364.
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