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Chemical Structure : E260
CAS No.: 1241537-79-0
Catalog No.: PC-62649Not For Human Use, Lab Use Only.
E260 is a novel inhibitor of the Fer/FerT kinase with Kd of 0.85 uM, selectively evokes metabolic stress and necrotic death in cancer cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $178 | In stock | |
| 10 mg | $288 | In stock | |
| 25 mg | $458 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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E260 is a novel inhibitor of the Fer/FerT kinase with Kd of 0.85 uM, selectively evokes metabolic stress and necrotic death in cancer cells.
E260 compromises mitochondrial integrity, and activates PARP-1 and autophagy, thereby targeting the energy management system of cancer cells.
E260 exhibits an viability EC50 of 400 nM after 24 h of treatment and an EC50 of 300 nM after 48 h in metastatic SW620 cells.
E260 suppresses xenografts progression in vivo.
| M.Wt | 438.638 | |
| Formula | C24H34N6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-(4-isopropylphenyl)-2-(4-((4-methylpiperazin-1-yl)methyl)piperidin-1-yl)imidazo[2,1-b][1,3,4]thiadiazole |
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1. Elkis Y, et al. Nat Commun. 2017 Oct 16;8(1):940.
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