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E6060

Chemical Structure : E6060

CAS No.: 196518-98-6

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E6060 (E 6060)

Catalog No.: PC-21837Not For Human Use, Lab Use Only.

E6060 is a potent, selective retinoic acid receptor subtype α (RAR-α) agonist with Ki of 0.2 nM, IC50 of 0.2 nM for RAR-α-mediated reporter transactivation assays.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

E6060 is a potent, selective retinoic acid receptor subtype α (RAR-α) agonist with Ki of 0.2 nM, IC50 of 0.2 nM for RAR-α-mediated reporter transactivation assays.
E6060 does not induce reporter transactivation through any of the RXR homodimers (RXR-α, RXR-β, and RXR-γ) at 3000 nM.
E6060 at 0.03 and 0.1 mg/kg (once daily, p.o.) significantly improved survival rate and prevented the development of proteinuria in (NZBxNZW)F1 mice.
E6060 also reduced anti-DNA autoantibodies and total serum IgG in E6060-treated mice.

Physicochemical Properties

M.Wt 389.31
Formula C20H11F4NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-{5-[7-fluoro-4-(trifluoromethyl)benzo[b]furan-2-yl]-1H-2-pyrrolyl}benzoic acid

References

1. Yamauchi T, et al. J Pharmacol Exp Ther. 2005 Mar;312(3):938-44.

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