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Chemical Structure : E6060
Catalog No.: PC-21837Not For Human Use, Lab Use Only.
E6060 is a potent, selective retinoic acid receptor subtype α (RAR-α) agonist with Ki of 0.2 nM, IC50 of 0.2 nM for RAR-α-mediated reporter transactivation assays.
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E6060 is a potent, selective retinoic acid receptor subtype α (RAR-α) agonist with Ki of 0.2 nM, IC50 of 0.2 nM for RAR-α-mediated reporter transactivation assays.
E6060 does not induce reporter transactivation through any of the RXR homodimers (RXR-α, RXR-β, and RXR-γ) at 3000 nM.
E6060 at 0.03 and 0.1 mg/kg (once daily, p.o.) significantly improved survival rate and prevented the development of proteinuria in (NZBxNZW)F1 mice.
E6060 also reduced anti-DNA autoantibodies and total serum IgG in E6060-treated mice.
| M.Wt | 389.31 | |
| Formula | C20H11F4NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yamauchi T, et al. J Pharmacol Exp Ther. 2005 Mar;312(3):938-44.
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