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E67-2

Chemical Structure : E67-2

CAS No.: 1364914-62-4

E67-2 (KDM7A inhibitor E67-2)

Catalog No.: PC-61816Not For Human Use, Lab Use Only.

E67-2 is a potent and selective inhibitor of H3K9 Jumonji demethylase KIAA1718 (KDM7A) with IC50 of 3.4 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    E67-2 is a potent and selective inhibitor of H3K9 Jumonji demethylase KIAA1718 (KDM7A) with IC50 of 3.4 uM.
    E67-2 selectively inhibits H3K9 Jumonji demethylase over H3K9 methyltransferase as well as H3K4 demethylase, has low cytotoxicity.

    Physicochemical Properties

    M.Wt 404.559
    Formula C21H36N6O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    7-((5-aminopentyl)oxy)-N2-(3-(dimethylamino)propyl)-6-methoxy-N4,N4-dimethylquinazoline-2,4-diamine

    References

    1. Upadhyay AK, et al. J Mol Biol. 2012 Feb 24;416(3):319-27.

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