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Chemical Structure : E745-0011
Catalog No.: PC-22326Not For Human Use, Lab Use Only.
E745-0011 is a small molecule inhibitor of tumor necrosis factor-α-induced protein 8-like 3 (TNFAIP8L3, TIPE3), exhibits potent anti-tumor activities.
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E745-0011 is a small molecule inhibitor of tumor necrosis factor-α-induced protein 8-like 3 (TNFAIP8L3, TIPE3), exhibits potent anti-tumor activities.
E745-0011 induces a dose-dependent decrease in the viability of HT-29 cells and LoVo cells, with IC50 values of 15-20 uM, respectively.
E745-0011 is effective against colon-cancer-derived cell lines in vitro while having no toxicity to normal human primary cells.
| M.Wt | 422.47 | |
| Formula | C23H19FN2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen X, et al. Cells. 2024 Apr 30;13(9):771.
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