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Chemical Structure : EC144
CAS No.: 911397-80-3
Catalog No.: PC-21226Not For Human Use, Lab Use Only.
EC144 (EC-144) is a potent, second generation inhibitor of heat shock protein 90 (Hsp90) with IC50 of 1.1 nM in Hsp90α binding assay, degrades Her-2 in MCF-7 cells with EC50 of 14 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $388 | In stock | |
| 25 mg | $588 | In stock | |
| 100 mg | Get quote |
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EC144 (EC-144) is a potent, second generation inhibitor of heat shock protein 90 (Hsp90) with IC50 of 1.1 nM in Hsp90α binding assay, degrades Her-2 in MCF-7 cells with EC50 of 14 nM.
EC144 inhibits tumor growth at 5 mg/kg and causes partial tumor regressions at 10 mg/kg (po, qd × 5) in mouse model of gastric tumors (N87).
EC144 is approximately 20-fold more efficacious than BIIB021 (Cat# PC-42459).
EC144 blocks LPS-induced TLR4 signaling in RAW 264.7 cells by inhibiting activation of ERK1/2, MEK1/2, JNK, and p38 MAPK but not NF-κB.
EC144 blocks disease development in rat collagen-induced arthritis by suppressing the inflammatory response.
| M.Wt | 413.91 | |
| Formula | C21H24ClN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methylpent-4-yn-2-ol |
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1. Shi J, et al. J Med Chem. 2012 Sep 13;55(17):7786-95.
2. Yun TJ, et al. J Immunol. 2011 Jan 1;186(1):563-75.
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