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EC330

Chemical Structure : EC330

CAS No.: 2016795-77-8

EC330 (EC-330, LIF inhibitor EC330)

Catalog No.: PC-42293Not For Human Use, Lab Use Only.

EC330 (EC-330, EC 330) is a first-in-class, ​orally bioavailable LIF (leukemia inhibitory factor) inhibitor.

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Biological Activity

EC330 (EC-330, EC 330) is a first-in-class, orally bioavailable LIF (leukemia inhibitory factor) inhibitor.
EC330 shows cytotoxicity in various cancer cell line and NCI-60 cell line panel at low nano-molar range; reduces tumor burden in ovarian (IGROV-1) and triple negative breast cancer (MDA-MB-231) cell xenografted mouse models as well as MDA-MB-231 PDX models; orally bioavailable.

Physicochemical Properties

M.Wt 462.5706864
Formula C30H32F2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Estra-4,9-dien-3-one, 11-(4-cyclopropylphenyl)-17-(1,1-difluoro-2-propyn-1-yl)-17-hydroxy-, (11β,17β)-

References

1. Nair HB, et al. Discovery and preclinical pharmacology of EC330: A first-in-class leukemia inhibitory factor (LIF) inhibitor.

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