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ECF inhibitor 1

Chemical Structure : ECF inhibitor 1

CAS No.: 1984038-17-6

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ECF inhibitor 1

Catalog No.: PC-21409Not For Human Use, Lab Use Only.

ECF inhibitor 1 is a specific small molecule inhibitor of energy-coupling factor (ECF) transporters, potentially acting as protein-protein interaction (PPI) modulator.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ECF inhibitor 1 is a specific small molecule inhibitor of energy-coupling factor (ECF) transporters, potentially acting as protein-protein interaction (PPI) modulator.
ECF inhibitor 1 is able to reduce translocation of the vitamin across the membrane with an IC50 value of 282  μM.
ECF inhibitor 1 (5 mM) is able to completely inhibit the transport of folate by ECF-FolT2.
ECF inhibitor 1 does not impact classical ABC transporters in general. inhibited the uptake of pantothenate via ECF-PanT in liposomes.

Physicochemical Properties

M.Wt 294.31
Formula C18H14O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-hydroxy-5-(naphthalen-1-ylmethoxy)benzoic acid

References

1. Diamanti E, et al. Commun Biol. 2023 Nov 20;6(1):1182.

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