EDG-7499 | Cardiac sarcomere modulator, Myofibril ATPase inhibitor

Chemical Structure : EDG-7499

Catalog No.: PC-28302Not For Human Use, Lab Use Only.

EDG-7499 a systolic-selective cardiac sarcomere modulator (s-CSM), modulates myosin ATPase indirectly via the myosin RLC.

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Biological Activity

EDG-7499 a systolic-selective cardiac sarcomere modulator (s-CSM), modulates myosin ATPase indirectly via the myosin RLC.

M.Wt	389.34
Formula	C18H14F3N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(1-(5-cyano-3-fluoropyridin-2-yl)ethyl)-2-(5,6-difluoro-2-oxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide

1. Li-Wen Chu E, et al. Card Fail Rev. 2025 Nov 3;11:e27.

2. Emter CA, et al. JCI Insight. 2026 Sep 22;11(18):e203086.