EGX358 | ERβ agonist | Probechem Biochemicals

Chemical Structure : EGX358

EGX358 (ISP358-2)

Catalog No.: PC-23654Not For Human Use, Lab Use Only.

EGX358 (ISP358-2) is a potent, highly selective estrogen receptor-beta (ERβ) agonist with EC50 of 27 nM, 750-fold selectivity for ERβ over ERα.

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Biological Activity

EGX358 (ISP358-2) is a potent, highly selective estrogen receptor-beta (ERβ) agonist with EC50 of 27 nM, 750-fold selectivity for ERβ over ERα.
EGX358 (ISP358-2) shows no antagonist activity for ERβ or ERα at concentrations up to 10 μM.
EGX358 (ISP358-2) shows in vivo efficacy after microinfusion into the dorsal hippocampus and after intraperitoneal injection (0.5 mg/kg) or oral gavage (0.5 mg/kg).

Physicochemical Properties

M.Wt	206.29
Formula	C13H18O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[trans-(4-hydroxymethyl)cyclohexyl]phenol

References

1. Hanson AM, et al. J Med Chem. 2018 Jun 14;61(11):4720-4738.

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EGX358 (ISP358-2)

Biological Activity

Physicochemical Properties

References

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