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Chemical Structure : ELQ-598
Catalog No.: PC-22514Not For Human Use, Lab Use Only.
ELQ-598 is a endochin-like quinolone compound with potent antibabesial activity with IC50 of 37 nM against B. duncani in human erythrocytes, the prodrug of ELQ-596.
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ELQ-598 is a endochin-like quinolone compound with potent antibabesial activity with IC50 of 37 nM against B. duncani in human erythrocytes, the prodrug of ELQ-596.
ELQ-598 display no cytotoxity against human cell lines: HeLa, HepG2, HEK293, and HCT116 (IC50>10 uM).
ELQ-598 (daily dose, 10 mg/kg from DPI 3–7) eliminates B. duncani in vivo, protects mice from B. duncani lethal infection mouse model.
ELQ-598 + atovaquone effectively eliminate B. microti and B. duncani infections in mice.
| M.Wt | 561.94 | |
| Formula | C28H23ClF3NO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pratap Vydyam, et al. ACS Infect Dis. 2024 Apr 12;10(4):1405-1413.
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