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ELQ-598

Chemical Structure : ELQ-598

CAS No.: 3023709-99-8

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ELQ-598 (ELQ598)

Catalog No.: PC-22514Not For Human Use, Lab Use Only.

ELQ-598 is a endochin-like quinolone compound with potent antibabesial activity with IC50 of 37 nM against B. duncani in human erythrocytes, the prodrug of ELQ-596.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ELQ-598 is a endochin-like quinolone compound with potent antibabesial activity with IC50 of 37 nM against B. duncani in human erythrocytes, the prodrug of ELQ-596.
ELQ-598 display no cytotoxity against human cell lines: HeLa, HepG2, HEK293, and HCT116 (IC50>10 uM).
ELQ-598 (daily dose, 10 mg/kg from DPI 3–7) eliminates B. duncani in vivo, protects mice from B. duncani lethal infection mouse model.
ELQ-598 + atovaquone effectively eliminate B. microti and B. duncani infections in mice.

Physicochemical Properties

M.Wt 561.94
Formula C28H23ClF3NO6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

((6-chloro-7-methoxy-2-methyl-3-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)quinolin-4-yl)oxy)methyl ethyl carbonate

References

1. Pratap Vydyam, et al. ACS Infect Dis. 2024 Apr 12;10(4):1405-1413.

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