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ELQ-672

Chemical Structure : ELQ-672

CAS No.: 3023710-80-4

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ELQ-672 (ELQ672)

Catalog No.: PC-22515Not For Human Use, Lab Use Only.

ELQ-672 is a endochin-like quinolone compound with potent antibabesial activity with IC50 of 57 nM against B. duncani in human erythrocytes.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ELQ-672 is a endochin-like quinolone compound with potent antibabesial activity with IC50 of 57 nM against B. duncani in human erythrocytes.
ELQ-672 display no cytotoxity against human cell lines: HeLa, HepG2, HEK293, and HCT116 (IC50>10 uM).
ELQ-672(daily dose, 10 mg/kg from DPI 3–7) eliminates B. duncani in vivo, protects mice from B. duncani lethal infection mouse model.
ELQ-672 + atovaquone effectively eliminate B. microti and B. duncani infections in mice.

Physicochemical Properties

M.Wt 545.49
Formula C28H23F4NO6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ethyl (((6-fluoro-7-methoxy-2-methyl-3-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)quinolin-4-yl)oxy)methyl) carbonate

References

1. Pratap Vydyam, et al. ACS Infect Dis. 2024 Apr 12;10(4):1405-1413.

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