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EN460

Chemical Structure : EN460

CAS No.: 496807-64-8

EN460 (EN-460)

Catalog No.: PC-43248Not For Human Use, Lab Use Only.

EN460 is a specific mall molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1), interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation (IC50=1.9 uM).

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Biological Activity

EN460 is a specific mall molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1), interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation (IC50=1.9 uM).
EN460 promotes signaling in the unfolded protein response and precondition cells against severe ER stress.
EN460 shows a dose response effect on the embryos with a dose of 10 uM being significantly lethal during early embryonic development.

Physicochemical Properties

M.Wt 460.7899
Formula C22H12ClF3N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzoic acid, 2-chloro-5-[4,5-dihydro-5-oxo-4-[(5-phenyl-2-furanyl)methylene]-3-(trifluoromethyl)-1H-pyrazol-1-yl]-

References

1. Blais JD, et al. J Biol Chem. 2010 Jul 2;285(27):20993-1003.

2. Geldenhuys WJ, et al. Bioorg Med Chem Lett. 2017 May 1;27(9):2029-2037.

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