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ENMD-1068

Chemical Structure : ENMD-1068

CAS No.: 789488-77-3

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ENMD-1068 (ENMD1068)

Catalog No.: PC-61561Not For Human Use, Lab Use Only.

ENMD-1068 is a novel selective PAR2 antagonist without inhibitory activity against thrombin-mediated PAR3 and PAR4 signaling.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ENMD-1068 is a novel selective PAR2 antagonist without inhibitory activity against thrombin-mediated PAR3 and PAR4 signaling.
ENMD-1068 blocks TNFα production in synovial explants from patients with arthritis.
ENMD-1068 inhibits mast cell tryptase-induced recruitment of eosinophils into the pleural cavity of mice, dose dependently attenuates joint inflammation.

Physicochemical Properties

M.Wt 283.416
Formula C15H29N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N1-3-methylbutyryl-N4-6-aminohexanoyl-piperazine

References

1. Kelso EB, et al. J Pharmacol Exp Ther. 2006 Mar;316(3):1017-24.

2. Kelso EB, et al. Arthritis Rheum. 2007 Mar;56(3):765-71.

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