Chemical Structure : ENMD-1068 hydrochloride
CAS No.: 2703451-51-6
Catalog No.: PC-61560Not For Human Use, Lab Use Only.
ENMD-1068 is a novel selective PAR2 antagonist without inhibitory activity against thrombin-mediated PAR3 and PAR4 signaling.
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ENMD-1068 hydrochloride is a novel selective PAR2 antagonist without inhibitory activity against thrombin-mediated PAR3 and PAR4 signaling.
ENMD-1068 blocks TNFα production in synovial explants from patients with arthritis, and inhibits mast cell tryptase-induced recruitment of eosinophils into the pleural cavity of mice, dose dependently attenuates joint inflammation.
M.Wt | 319.87 | |
Formula | C15H29N3O2.HCl | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
N1-3-methylbutyryl-N4-6-aminohexanoyl-piperazine hydrochloride |
1. Kelso EB, et al. J Pharmacol Exp Ther. 2006 Mar;316(3):1017-24.
2. Kelso EB, et al. Arthritis Rheum. 2007 Mar;56(3):765-71.
3. Lohman RJ, et al. J Pharmacol Exp Ther. 2012 Feb;340(2):256-65.
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