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ENMD-2076

Chemical Structure : ENMD-2076

CAS No.: 934353-76-1

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ENMD-2076 (ENMD 2076;ENMD2076)

Catalog No.: PC-42766Not For Human Use, Lab Use Only.

ENMD-2076 is a multitargeted kinase inhibitor with IC50s of 3/14/23/40 nM for Flt3/Aurora A/Src/VEGFR2, respectively.

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10 mg $88 In stock
25 mg $138 In stock
50 mg $218 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ENMD-2076 is a multitargeted kinase inhibitor with IC50s of 3/14/23/40 nM for Flt3/Aurora A/Src/VEGFR2, respectively.
ENMD-2076 also inhibits Aurora B, c-Kit, FGFR1 (IC50=100-350 nM).
ENMD-2076 is orally bioactive.

Physicochemical Properties

M.Wt 375.4701
Formula C21H25N7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-Pyrimidinamine, 6-(4-methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(1E)-2-phenylethenyl]-

References

1. Tentler JJ, et al. Clin Cancer Res. 2010 Jun 1;16(11):2989-98.

2. Matulonis UA, et al. Eur J Cancer. 2013 Jan;49(1):121-31.

3. Fletcher GC, et al. Mol Cancer Ther. 2011 Jan;10(1):126-37.

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