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EOAI3402143

Chemical Structure : EOAI3402143

CAS No.: 1699750-95-2

EOAI3402143 (Deubiquitinase inhibitor G9;EOAI 3402143)

Catalog No.: PC-61303Not For Human Use, Lab Use Only.

EOAI3402143 (Deubiquitinase inhibitor G9, EOAI 3402143) is a novel covalent deubiquitinase Usp9x/Usp24 inhibitor (IC50=1.6 uM).

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Biological Activity

EOAI3402143 (Deubiquitinase inhibitor G9, EOAI 3402143) is a novel covalent deubiquitinase Usp9x/Usp24 inhibitor (IC50=1.6 uM).
EOAI3402143 shows increased aqueous solubility and greater cellular Usp9x inhibitory activity than WP1130.
EOAI3402143 displays nM apoptotic activity against other myeloma cell lines and diffuse large B-cell lymphomas cells.
EOAI3402143 increases tumor cell apoptosis, and fully blocks or regresses myeloma tumors in mice; also inhibis Usp5.

Physicochemical Properties

M.Wt 503.424
Formula C25H28Cl2N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-2-cyano-3-(3,6-dichloropyridin-2-yl)-N-(1-(4-(2-morpholinoethoxy)phenyl)butyl)acrylamide

References

1. Peterson LF, et al. Blood. 2015 Jun 4;125(23):3588-97.

2. Potu H, et al. Oncotarget. 2014 Jul 30;5(14):5559-69.

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