Chemical Structure : EOAI3402143
CAS No.:
1699750-95-2
EOAI3402143
(Deubiquitinase inhibitor G9;EOAI 3402143)
Catalog No.: PC-61303Not For Human Use, Lab Use Only.
EOAI3402143 (Deubiquitinase inhibitor G9, EOAI 3402143) is a novel covalent deubiquitinase Usp9x/Usp24 inhibitor (IC50=1.6 uM).
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
EOAI3402143 (Deubiquitinase inhibitor G9, EOAI 3402143) is a novel covalent deubiquitinase Usp9x/Usp24 inhibitor (IC50=1.6 uM).
EOAI3402143 shows increased aqueous solubility and greater cellular Usp9x inhibitory activity than WP1130.
EOAI3402143 displays nM apoptotic activity against other myeloma cell lines and diffuse large B-cell lymphomas cells.
EOAI3402143 increases tumor cell apoptosis, and fully blocks or regresses myeloma tumors in mice; also inhibis Usp5.
Physicochemical Properties
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M.Wt
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503.424
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Formula
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C25H28Cl2N4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-2-cyano-3-(3,6-dichloropyridin-2-yl)-N-(1-(4-(2-morpholinoethoxy)phenyl)butyl)acrylamide
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References
1. Peterson LF, et al. Blood. 2015 Jun 4;125(23):3588-97.
2. Potu H, et al. Oncotarget. 2014 Jul 30;5(14):5559-69.
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