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Chemical Structure : EP009
Catalog No.: PC-61263Not For Human Use, Lab Use Only.
EP009 is a selective, orally active JAK3 inhibitor that reduces IL-2-mediated JAK3 tyrosine phosphorylation with cellular IC50 of 10-20 uM.
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EP009 is a selective, orally active JAK3 inhibitor that reduces IL-2-mediated JAK3 tyrosine phosphorylation with cellular IC50 of 10-20 uM.
EP009 exhibits limited off-target effects against a panel of 92 human kinases.
EP009 inhibits tyrosine phosphorylation and activation of JAK3/STAT3 in SU-DHL-1 cells, with activation of JNK1/2, but not p38.
EP009 displays a favorable cytotoxicity profile with therapeutic efficacy against JAK3-driven tumor T-cells in vitro, in vivo, and ex vivo.
| M.Wt | 224.344 | |
| Formula | C14H24O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ross JA, et al. Leukemia. 2014 Apr;28(4):941-4.
2. Martinez GS, et al. Clin Cancer Drugs. 2016;3(2):131-137.
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