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EP009

Chemical Structure : EP009

CAS No.: 1462951-30-9

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EP009 (EP-009;EP 009)

Catalog No.: PC-61263Not For Human Use, Lab Use Only.

EP009 is a selective, orally active JAK3 inhibitor that reduces IL-2-mediated JAK3 tyrosine phosphorylation with cellular IC50 of 10-20 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    EP009 is a selective, orally active JAK3 inhibitor that reduces IL-2-mediated JAK3 tyrosine phosphorylation with cellular IC50 of 10-20 uM.
    EP009 exhibits limited off-target effects against a panel of 92 human kinases.
    EP009 inhibits tyrosine phosphorylation and activation of JAK3/STAT3 in SU-DHL-1 cells, with activation of JNK1/2, but not p38.
    EP009 displays a favorable cytotoxicity profile with therapeutic efficacy against JAK3-driven tumor T-cells in vitro, in vivo, and ex vivo.

    Physicochemical Properties

    M.Wt 224.344
    Formula C14H24O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(hydroxymethyl)-12-methylenecyclododecanone

    References

    1. Ross JA, et al. Leukemia. 2014 Apr;28(4):941-4.

    2. Martinez GS, et al. Clin Cancer Drugs. 2016;3(2):131-137.

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