Chemical Structure : EPB-113
CAS No.:
EPB-113
(EPB113)
Catalog No.: PC-23977Not For Human Use, Lab Use Only.
EPB-113 is a potent replication inhibitor of HCoV-229E with EC50 of 0.48 uM, also suppresses SARS-CoV-2, binds to hexameric nsp15 protein.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
EPB-113 is a potent replication inhibitor of HCoV-229E with EC50 of 0.48 uM, also suppresses SARS-CoV-2, binds to hexameric nsp15 protein.
EPB-113 shows an EC90 value of 0.65 µM based on RT-qPCR for viral genome copies and of 0.40 µM based on titration of infectious virus inHCoV-229E-infected HEL299 cells.
EPB-113 inhibits SARS-CoV-2 replication in A549ACE2/TMPRSS2 cells. The molecule was shown to have an EC90 value (by RT-qPCR for viral load) of 12 µM and to produce more than 5-log10 reduction in viral load at 50 µM.
The antiviral effect of EPB-113 is tightly linked with nsp15, and specifically its EndoU domain, enhances the EndoU cleavage reaction
EPB-113 is active in both IFN responsive and non-responsive cell types.
EPB-113 acts at a post-entry and intermediate stage in first-cycle HCoV-229E replication.
Physicochemical Properties
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M.Wt
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395.35
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Formula
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C14H14F5N5OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(NC1=CC=CC(NC(N)=N)=C1)NC2=CC(S(F)(F)(F)(F)F)=CC=C2
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References
1. Van Loy B, et al. PLoS Pathog. 2025 Feb 11;21(2):e1012571.
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