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EPI-589

Chemical Structure : EPI-589

CAS No.: 1147883-03-1

EPI-589 (EPI 589)

Catalog No.: PC-49719Not For Human Use, Lab Use Only.

EPI-589 (EPI 589) is an orally available, blood-brain barrier permeable redox-active agent characterized by highly potent protective effects against oxidative stress, attenuates oxidative stress due to the radical scavenging activity of the reduced form and affects mitochondrial energy metabolism as a substrate of quinone-oxidoreductases.

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    Biological Activity

    EPI-589 (EPI 589) is an orally available, blood-brain barrier permeable redox-active agent characterized by highly potent protective effects against oxidative stress, attenuates oxidative stress due to the radical scavenging activity of the reduced form and affects mitochondrial energy metabolism as a substrate of quinone-oxidoreductases.
    EPI-589 shows promise as a potential therapy for patients with amyotrophic lateral sclerosis (ALS).

    Physicochemical Properties

    M.Wt 265.31
    Formula C14H19NO4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (αR)-α-Hydroxy-α,2,4,5-tetramethyl-3,6-dioxo-1,4-cyclohexadiene-1-butanamide

    References

    1. Noda N, et al. Clin Pharmacol Drug Dev. 2022 Oct;11(10):1136-1146.

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