Chemical Structure : EPIC-1042
CAS No.:
372180-55-7
EPIC-1042
(EPIC1042)
Catalog No.: PC-25656Not For Human Use, Lab Use Only.
EPIC-1042 is a potent, small molecule PTRF/Cavin1-caveolin-1 interaction inhibitor with IC50 of 38 uM, inhibits the binding of PTRF to Caveolin-1 (CAV1), resulting in decreased secretion of small extracellular vesicles (sEVs).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
EPIC-1042 is a potent, small molecule PTRF/Cavin1-caveolin-1 interaction inhibitor with IC50 of 38 uM, inhibits the binding of PTRF to Caveolin-1 (CAV1), resulting in decreased secretion of small extracellular vesicles (sEVs).
EPIC-1042 prevents temozolomide efflux by inhibiting small extracellular vesicles secretion, inhibits autophagy flux in the later stage.
EPIC-1042 could specifically inhibit the secretion of sEVs by disrupting the interaction between PTRF and CAV1.
EPIC-1042 inhibits autophagy flux and increase TMZ sensitivity in vivo.
EPIC-1042 could enhance TMZ efficacy in MGMT-deficient GBM tumors in vivo.
EPIC-1042 induces p62-mediated autophagic PARP1 degradation.
EPIC-1042 enhances TMZ sensitivity in MGMT-positive GBM cells.
EPIC-1042 enhances TMZ sensitivity in dose-dependent and long-term treatment manners in MGMT-deficient tumors in vivo.
Physicochemical Properties
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M.Wt
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350.47
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Formula
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C20H26N6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-((2-aminoethyl)amino)-1-(benzylamino)-7-ethyl-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile
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References
1. Hong B, et al. Neuro Oncol. 2024 Jan 5;26(1):100-114.
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