Catalog No.: PC-61073Not For Human Use, Lab Use Only.
EPPTB (Ro 5212773) is a potent, selective mouse TAAR1 antagonist that potently antagonizes cAMP production induced by 1.5 uM β-phenylethylamine with IC50 of 27.5 nM, Ki of 1 nM.
EPPTB (Ro 5212773) is a potent, selective mouse TAAR1 antagonist that potently antagonizes cAMP production induced by 1.5 uM β-phenylethylamine with IC50 of 27.5 nM, Ki of 1 nM.
EPPTB (Ro 5212773) displays >1,000-fold selectivity over dopamine, serotonin and adrenergic receptors.
EPPTB (Ro 5212773) dose-dependently reduces cAMP levels in HEK293 cells in the absence of TAAR1 agonist with IC50 of 19±12 nM, significantly more potent in antagonizing cAMP production by mouse, as compared to rat and human.
EPPTB (Ro 5212773)blocks the TAAR1-mediated activation of an inwardly rectifying K(+) current at dopamine (DA) neurons of the ventral tegmental area.
