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Chemical Structure : EPZ020411 hydrochloride
CAS No.: 2070015-25-5
Catalog No.: PC-43301Not For Human Use, Lab Use Only.
EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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EPZ020411 hydrochloride is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7).
EPZ020411 dose-dependently decreases H3R2 methylation A375 cell line with IC50 of 0.637 uM, with no affect levels of PRMT6 expression.
EPZ020411 exhibits good bioavailability following subcutaneous dosing in rats making it a suitable tool for potential in vivo target validation studies.
| M.Wt | 479.0551 | |
| Formula | C25H39ClN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
H2O: ≥ 41 mg/mL |
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| Chemical Name/SMILES |
1,2-Ethanediamine, N1,N2-dimethyl-N1-[[3-[4-[[trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl]oxy]phenyl]-1H-pyrazol-4-yl]methyl]-,hydrochloride |
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1. Mitchell LH, et al. ACS Med Chem Lett. 2015 Apr 6;6(6):655-9.
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