Chemical Structure : ER-38925
CAS No.:
196517-43-8
ER-38925
(ER38925)
Catalog No.: PC-21833Not For Human Use, Lab Use Only.
ER-38925 is a potent, selective retinoic acid receptor subtype α (RAR-α) agonist, inhibits proliferation of mouse spleen cells with IC50 of 0.2 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ER-38925 is a potent, selective retinoic acid receptor subtype α (RAR-α) agonist, inhibits proliferation of mouse spleen cells with IC50 of 0.2 nM.
ER-38925 binds to RARα and induces transactivation with high potency.
ER-38925 remarkably inhibits cytotoxic T lymphocyte induction and alloantigen‐stimulated production of cytokines, i.e. IL‐2, IL‐12 and IFN‐γ.
ER‐38925 reduces the grade and incidence of arteriosclerosis in the cardiac allografts in chronic rejection models.
ER‐38925 inhibits the proliferation of rat aortic smooth muscle cells stimulated in vitro, presumably through the induction of a cyclin‐dependent kinase inhibitor, p27kip‐1.
Physicochemical Properties
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M.Wt
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331.37
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Formula
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C21H17NO3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(5-(4,7-dimethylbenzofuran-2-yl)-1H-pyrrol-2-yl)benzoic acid
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References
1. T Hida, et al. Drug Discov Ther. 2008 Feb;2(1):35-44.
2. Ken-ichiro Seino, et al. Int Immunol. 2004 May;16(5):665-73.
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