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Chemical Structure : ERD03
CAS No.: 1377897-01-2
Catalog No.: PC-35611Not For Human Use, Lab Use Only.
ERD03 (EXOSC3-RNA disrupting compound 3) is a small molecule EXOSC3-RNA disrupting (ERD) compound that binds specifically to EXOSC3 (Kd=17 uM), induces a PCH1B-like phenotype in zebrafish.
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| 5 mg | $358 | In stock | |
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ERD03 (EXOSC3-RNA disrupting compound 3) is a small molecule EXOSC3-RNA disrupting (ERD) compound that binds specifically to EXOSC3 (Kd=17 uM), induces a PCH1B-like phenotype in zebrafish.
ERD03 recapitulates EXOSC3 knock-down effects on RNA transcriptomic profiles in zebrafish.
ERD03 induces an atrophy of the zebrafish cerebellum, a clinical feature of PCH1B, also induces modification of zebrafish RNA expression levels similar to that observed with a morpholino against EXOSC3.
| M.Wt | 339.44 | |
| Formula | C21H25NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3,4-Dihydro-4-hydroxy-2(1H)-isoquinolinyl)[3-(3-hydroxy-3-methylbutyl)phenyl]methanone |
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1. Francois-Moutal L, et al. ACS Chem Biol. 2018 Aug 24. doi: 10.1021/acschembio.8b00745.
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